A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP

The innate immune system responds to unique molecular signatures that are widely conserved among microbes but that are not normally present in host cells. Compounds that stimulate innate immune pathways may be valuable in the design of novel adjuvants, vaccines, and other immunotherapeutics. The cyc...

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Autors principals: McWhirter, Sarah M., Barbalat, Roman, Monroe, Kathryn M., Fontana, Mary F., Hyodo, Mamoru, Joncker, Nathalie T., Ishii, Ken J., Akira, Shizuo, Colonna, Marco, Chen, Zhijian J., Fitzgerald, Katherine A., Hayakawa, Yoshihiro, Vance, Russell E.
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2009
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2737161/
https://ncbi.nlm.nih.gov/pubmed/19652017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20082874
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