A novel mechanism of sodium iodide symporter repression in differentiated thyroid cancer

Differentiated thyroid cancers and their metastases frequently exhibit reduced iodide uptake, impacting on the efficacy of radioiodine ablation therapy. PTTG binding factor (PBF) is a proto-oncogene implicated in the pathogenesis of thyroid cancer. We recently reported that PBF inhibits iodide uptak...

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Bibliographic Details
Main Authors: Smith, Vicki E., Read, Martin L., Turnell, Andrew S., Watkins, Rachel J., Watkinson, John C., Lewy, Greg D., Fong, Jim C. W., James, Sally R., Eggo, Margaret C., Boelaert, Kristien, Franklyn, Jayne A., McCabe, Christopher J.
Format: Artigo
Language:Inglês
Published: Company of Biologists 2009
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2736868/
https://ncbi.nlm.nih.gov/pubmed/19706688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.045427
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