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Residues Leu261, Trp264, and Phe265 Account for Apolipoprotein E-Induced Dyslipidemia and Affect the Formation of Apolipoprotein E-Containing High-Density Lipoprotein

Overexpression of apolipoprotein E (apoE) induces hypertriglyceridemia in apoE-deficient mice, which is abrogated by deletion of the carboxy-terminal segment of residues 260–299. We have used adenovirus-mediated gene transfer in apoE(−/−) and apoA-I(−/−) mice to test the effect of three sets of apoE...

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Hlavní autoři: Drosatos, Konstantinos, Kypreos, Kyriakos E., Zannis, Vassilis I.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2007
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2736595/
https://ncbi.nlm.nih.gov/pubmed/17655277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi700232g
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