Measuring prions by bioluminescence imaging

Prions are infectious proteins that cause fatal neurodegenerative diseases. Because astrocytic gliosis marked by the deposition of fibrils composed of GFAP is a prominent feature of prion disease, we asked whether GFAP might be used as a surrogate marker for prions. To interrogate this posit, we ino...

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Autors principals: Tamgüney, Gültekin, Francis, Kevin P., Giles, Kurt, Lemus, Azucena, DeArmond, Stephen J., Prusiner, Stanley B.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2009
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2736416/
https://ncbi.nlm.nih.gov/pubmed/19706444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0907339106
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