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Total Synthesis of (+)-Superstolide A

A convergent and highly stereocontrolled total synthesis of the cytotoxic macrolide (+)-superstolide A is described. Key features of this synthesis include the use of bimetallic linchpin 36b for uniting the C(1)-C(15) (43) and the C(20)-C(27) (38) fragments of the natural product, a late-stage Suzuk...

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Autors principals: Tortosa, Mariola, Yakelis, Neal A., Roush, William R.
Format: Artigo
Idioma:Inglês
Publicat: 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2736345/
https://ncbi.nlm.nih.gov/pubmed/18956845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo801794s
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