EphA2 Immunoconjugate as Molecularly Targeted Chemotherapy for Ovarian Carcinoma

BACKGROUND: EphA2 is overexpressed in many types of human cancer but is absent or expressed at low levels in normal epithelial tissues. We investigated whether a novel immunoconjugate containing an anti-EphA2 monoclonal antibody (1C1) linked to a chemotherapeutic agent (monomethyl auristatin phenyla...

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Main Authors: Lee, Jeong-Won, Han, Hee Dong, Shahzad, Mian M. K., Kim, Seung Wook, Mangala, Lingegowda S., Nick, Alpa M., Lu, Chunhua, Langley, Robert R., Schmandt, Rosemarie, Kim, Hye-Sun, Mao, Shenlan, Gooya, John, Fazenbaker, Christine, Jackson, Dowdy, Tice, David A., Landen, Charles N., Coleman, Robert L., Sood, Anil K.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2009
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2736292/
https://ncbi.nlm.nih.gov/pubmed/19641174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/djp231
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