Antibody-mediated blockade of IL-15 reverses the autoimmune intestinal damage in transgenic mice that overexpress IL-15 in enterocytes

Celiac disease (CD) is an autoimmune inflammatory disease with a relatively high prevalence especially in the western hemisphere. A strong genetic component is involved in the pathogenesis of CD with virtually all individuals that develop the disease carrying HLA-DQ alleles that encode specific HLA-...

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Main Authors: Yokoyama, Seiji, Watanabe, Nobumasa, Sato, Noriko, Perera, Pin-Yu, Filkoski, Lyvouch, Tanaka, Toshiyuki, Miyasaka, Masayuki, Waldmann, Thomas A., Hiroi, Takachika, Perera, Liyanage P.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2009
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2736142/
https://ncbi.nlm.nih.gov/pubmed/19805228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0908834106
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