Janus Kinase Inhibitor Tofacitinib Shows Potent Efficacy in a Mouse Model of Autoimmune Lymphoproliferative Syndrome (ALPS)

PURPOSE: Autoimmune lymphoproliferative syndrome (ALPS) is a non-malignant genetic disorder of lymphocyte homeostasis with defective Fas-mediated apoptosis. Current therapies for ALPS primarily target autoimmune manifestations with non-specific immune suppressants with variable success thus highligh...

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Published in:J Clin Immunol
Main Authors: Yokoyama, Seiji, Perera, Pin-Yu, Terawaki, Seigo, Watanabe, Nobumasa, Kaminuma, Osamu, Waldmann, Thomas A., Hiroi, Takachika, Perera, Liyanage P.
Format: Artigo
Language:Inglês
Published: 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7780245/
https://ncbi.nlm.nih.gov/pubmed/26453583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10875-015-0203-z
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