Llwytho...

Interception of the Enzymatic Conversion of Farnesyl Diphosphate to 5-Epi-Aristolochene by Using a Fluoro Substrate Analogue: 1-Fluorogermacrene A from (2E,6Z)-6-Fluorofarnesyl Diphosphate

Tobacco 5-epi-aristolochene synthase (TEAS) catalyzes the Mg(II)-dependent cyclizations and rearrangements of (E,E)-farnesyl diphosphate (PP) to the bicyclic sesquiterpene hydrocarbon via a tightly bound (+)-germacrene A as a deprotonated intermediate. With the native enzyme, only a few percent of t...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Faraldos, Juan A., Zhao, Yuxin, O'Maille, Paul E., Noel, Joseph P., Coates, Robert M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2007
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2735885/
https://ncbi.nlm.nih.gov/pubmed/17886322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.200700398
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