Autophagy Gene Variant IRGM −261T Contributes to Protection from Tuberculosis Caused by Mycobacterium tuberculosis but Not by M. africanum Strains

The human immunity-related GTPase M (IRGM) has been shown to be critically involved in regulating autophagy as a means of disposing cytosolic cellular structures and of reducing the growth of intracellular pathogens in vitro. This includes Mycobacterium tuberculosis, which is in agreement with findi...

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Autori principali: Intemann, Christopher D., Thye, Thorsten, Niemann, Stefan, Browne, Edmund N. L., Amanua Chinbuah, Margaret, Enimil, Anthony, Gyapong, John, Osei, Ivy, Owusu-Dabo, Ellis, Helm, Susanne, Rüsch-Gerdes, Sabine, Horstmann, Rolf D., Meyer, Christian G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2009
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2735778/
https://ncbi.nlm.nih.gov/pubmed/19750224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1000577
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