CTLA4 Autoimmunity-Associated Genotype Contributes to Severe Pulmonary Tuberculosis in an African Population

The gene of Cytotoxic T Lymphocyte-associated Antigen 4 (CTLA4), a negative regulator of T lymphocytes, contains a single-nucleotide polymorphism (SNP) at position +6230A->G (ct60A->G), which has been found associated with several autoimmune diseases and appears to reduce T-cell inhibitory act...

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Autores principales: Thye, Thorsten, Scarisbrick, Genevieve, Browne, Edmund N. L., Chinbuah, Margaret Amanua, Gyapong, John, Osei, Ivy, Owusu-Dabo, Ellis, Niemann, Stefan, Rüsch-Gerdes, Sabine, Meyer, Christian G., Horstmann, Rolf D.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2707621/
https://ncbi.nlm.nih.gov/pubmed/19609446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0006307
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