Overexpression of IGF-1 in Muscle Attenuates Disease in a Mouse Model of Spinal and Bulbar Muscular Atrophy

Expansion of a polyglutamine tract in the androgen receptor (AR) causes spinal and bulbar muscular atrophy (SBMA). We have previously shown that Akt-mediated phosphorylation of AR reduces ligand binding and attenuates the toxicity of mutant AR. Here we show that in cultured cells insulin-like growth...

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Detalhes bibliográficos
Main Authors: Palazzolo, Isabella, Stack, Conor, Kong, Lingling, Musaro, Antonio, Adachi, Hiroaki, Katsuno, Masahisa, Sobue, Gen, Taylor, J. Paul, Sumner, Charlotte, Fischbeck, Kenneth, Pennuto, Maria
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2735765/
https://ncbi.nlm.nih.gov/pubmed/19679072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2009.07.019
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