Deficiency of Thrombonspondin-1 Reduces Th17 Differentiation and Attenuates Experimental Autoimmune Encephalomyelitis

Transforming growth factor β (TGF-β) plays a role both in the induction of Treg and in the differentiation of the IL-17-secreting T cells (Th17) which drive inflammation in experimental autoimmune encephalomyelitis (EAE). We investigated the role that thrombospondin-1 (TSP-1) dependent activation of...

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Main Authors: Yang, Kaiyong, Vega, Jose L., Hadzipasic, Muhamed, Peron, Jean Pierre Schatzmann, Zhu, Bing, Carrier, Julia, Masli, Sharmila, Rizzo, Luiz Vicente, Weiner, Howard L.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2009
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2735759/
https://ncbi.nlm.nih.gov/pubmed/19181483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaut.2008.12.004
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