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MCCE2: Improving Protein pK(a) Calculations with Extensive Side Chain Rotamer Sampling

Multiconformation continuum electrostatics (MCCE) explores different conformational degrees of freedom in Monte Carlo calculations of protein residue and ligand pK(a)s. Explicit changes in side chain conformations throughout a titration create a position dependent, heterogeneous dielectric response...

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Bibliografiske detaljer
Main Authors: SONG, YIFAN, MAO, JUNJUN, GUNNER, M. R.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2735604/
https://ncbi.nlm.nih.gov/pubmed/19274707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcc.21222
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