Polyamine biosynthesis impacts cellular folate requirements necessary to maintain S-adenosylmethionine and nucleotide pools

Folate (vitamin B9) is utilized for synthesis of both S-adenosylmethionine (AdoMet) and deoxythymidine monophosphate (dTMP), which are required for methylation reactions and DNA synthesis, respectively. Folate depletion leads to an imbalance in both AdoMet and nucleotide pools, causing epigenetic an...

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Autores principales: Bistulfi, G., Diegelman, P., Foster, B. A., Kramer, D. L., Porter, C. W., Smiraglia, D. J.
Formato: Artigo
Lenguaje:Inglês
Publicado: The Federation of American Societies for Experimental Biology 2009
Materias:
Research Communications
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2735368/
https://ncbi.nlm.nih.gov/pubmed/19417083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.09-130708
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