Hypusine biosynthesis in β cells links polyamine metabolism to facultative cellular proliferation to maintain glucose homeostasis

Deoxyhypusine synthase (DHPS) utilizes the polyamine spermidine to catalyze the hypusine modification of the mRNA translation factor eIF5A and promotes oncogenesis through poorly-defined mechanisms. Because germline deletion of Dhps is embryonically lethal, its role in normal postnatal cellular func...

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Pubblicato in:Sci Signal
Autori principali: Levasseur, Esther M., Yamada, Kentaro, Piñeros, Annie R., Wu, Wenting, Syed, Farooq, Orr, Kara S., Anderson-Baucum, Emily, Mastracci, Teresa L., Maier, Bernhard, Mosley, Amber L., Liu, Yunlong, Bernal-Mizrachi, Ernesto, Alonso, Laura C., Scott, Donald, Garcia-Ocaña, Adolfo, Tersey, Sarah A., Mirmira, Raghavendra G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7202401/
https://ncbi.nlm.nih.gov/pubmed/31796630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aax0715
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