Polyamine biosynthesis impacts cellular folate requirements necessary to maintain S-adenosylmethionine and nucleotide pools

Folate (vitamin B9) is utilized for synthesis of both S-adenosylmethionine (AdoMet) and deoxythymidine monophosphate (dTMP), which are required for methylation reactions and DNA synthesis, respectively. Folate depletion leads to an imbalance in both AdoMet and nucleotide pools, causing epigenetic an...

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Bibliografiska uppgifter
Huvudupphovsmän: Bistulfi, G., Diegelman, P., Foster, B. A., Kramer, D. L., Porter, C. W., Smiraglia, D. J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The Federation of American Societies for Experimental Biology 2009
Ämnen:
Research Communications
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2735368/
https://ncbi.nlm.nih.gov/pubmed/19417083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.09-130708
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