Ethyl pyruvate decreases HMGB1 release and ameliorates murine colitis

Signals from stressed cells and the enteric microbiota activate macrophages and dendritic cells and mediate intestinal inflammation. HMGB1 serves as an immunogenic stimuli causing release of inflammatory cytokines by myeloid cells. Ethyl pyruvate inhibits secretion of HMGB1 and improves survival in...

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Bibliografske podrobnosti
Main Authors: Davé, Shaival H., Tilstra, Jeremy S., Matsuoka, Katsuyoshi, Li, Fengling, DeMarco, Richard A., Beer-Stolz, Donna, Sepulveda, Antonia R., Fink, Mitchell P., Lotze, Michael T., Plevy, Scott E.
Format: Artigo
Jezik:Inglês
Izdano: The Society for Leukocyte Biology 2009
Teme:
Primary Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2735284/
https://ncbi.nlm.nih.gov/pubmed/19454652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.1008662
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