Ethyl pyruvate decreases HMGB1 release and ameliorates murine colitis

Signals from stressed cells and the enteric microbiota activate macrophages and dendritic cells and mediate intestinal inflammation. HMGB1 serves as an immunogenic stimuli causing release of inflammatory cytokines by myeloid cells. Ethyl pyruvate inhibits secretion of HMGB1 and improves survival in...

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Detalhes bibliográficos
Main Authors: Davé, Shaival H., Tilstra, Jeremy S., Matsuoka, Katsuyoshi, Li, Fengling, DeMarco, Richard A., Beer-Stolz, Donna, Sepulveda, Antonia R., Fink, Mitchell P., Lotze, Michael T., Plevy, Scott E.
Formato: Artigo
Idioma:Inglês
Publicado em: The Society for Leukocyte Biology 2009
Assuntos:
Primary Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2735284/
https://ncbi.nlm.nih.gov/pubmed/19454652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.1008662
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