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Total Synthesis and Structure-Activity Investigation of the Marine Natural Product Neopeltolide
The total synthesis and biological evaluation of neopeltolide and analogs are reported. The key bond-forming step utilizes a Lewis acid-catalyzed intramolecular macrocyclization that installs the tetrahydropyran ring and macrocycle simultaneously. Independent of each other, neither the macrolide nor...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2735232/ https://ncbi.nlm.nih.gov/pubmed/19663512 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja904604x |
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