Cyclophosphamide Chemotherapy Sensitizes Tumor Cells to TRAIL-Dependent CD8 T Cell-Mediated Immune Attack Resulting in Suppression of Tumor Growth

BACKGROUND: Anti-cancer chemotherapy can be simultaneously lymphodepleting and immunostimulatory. Pre-clinical models clearly demonstrate that chemotherapy can synergize with immunotherapy, raising the question how the immune system can be mobilized to generate anti-tumor immune responses in the con...

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Main Authors: van der Most, Robbert G., Currie, Andrew J., Cleaver, Amanda L., Salmons, Joanne, Nowak, Anna K., Mahendran, Sathish, Larma, Irma, Prosser, Amy, Robinson, Bruce W. S., Smyth, Mark J., Scalzo, Anthony A., Degli-Esposti, Mariapia A., Lake, Richard A.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2009
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2734989/
https://ncbi.nlm.nih.gov/pubmed/19746156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0006982
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