The Snf1-related kinase, Hunk, is essential for mammary tumor metastasis

We previously identified a SNF1/AMPK-related protein kinase, Hunk, from a mammary tumor arising in an MMTV-neu transgenic mouse. The function of this kinase is unknown. Using targeted deletion in mice, we now demonstrate that Hunk is required for the metastasis of c-myc-induced mammary tumors, but i...

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Main Authors: Wertheim, Gerald B. W., Yang, Thomas W., Pan, Tien-chi, Ramne, Anna, Liu, Zhandong, Gardner, Heather P., Dugan, Katherine D., Kristel, Petra, Kreike, Bas, van de Vijver, Marc J., Cardiff, Robert D., Reynolds, Carol, Chodosh, Lewis A.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2009
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2734880/
https://ncbi.nlm.nih.gov/pubmed/19717424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0906993106
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