DNA vaccination in rhesus macaques induces potent immune responses and decreases acute and chronic viremia after SIVmac251 challenge

Optimized plasmid DNAs encoding the majority of SIVmac239 proteins and delivered by electroporation (EP) elicited strong immune responses in rhesus macaques. Vaccination decreased viremia in both the acute and chronic phases of infection after challenge with pathogenic SIVmac251. Two groups of macaq...

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Hlavní autoři: Rosati, Margherita, Bergamaschi, Cristina, Valentin, Antonio, Kulkarni, Viraj, Jalah, Rashmi, Alicea, Candido, Patel, Vainav, von Gegerfelt, Agneta S., Montefiori, David C., Venzon, David J., Khan, Amir S., Draghia-Akli, Ruxandra, Van Rompay, Koen K. A., Felber, Barbara K., Pavlakis, George N.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2009
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2734879/
https://ncbi.nlm.nih.gov/pubmed/19717425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0902628106
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