Cargando...

S K-edge XAS and DFT Calculations on Cytochrome P450: Covalent and Ionic Contributions to the Cysteine-Fe Bond and Their Contribution to Reactivity

Experimental covalencies of the Fe-S bond for the resting low-spin and substrate-bound high-spin active site of cytochrome P450 are reported. DFT calculations on the active site indicate that one H-bonding interaction from the protein backbone is needed to reproduce the experimental values. The H-bo...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Dey, Abhishek, Jiang, Yonging, de Montellano, Paul Ortiz, Hodgson, Keith O., Hedman, Britt, Solomon, Edward I.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2009
Materias:
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2734335/
https://ncbi.nlm.nih.gov/pubmed/19438234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja901868q
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!