Loss of Mitogen-Activated Protein Kinase Kinase Kinase 4 (MAP3K4) Reveals a Requirement for MAPK Signalling in Mouse Sex Determination

Sex determination in mammals is controlled by the presence or absence of the Y-linked gene SRY. In the developing male (XY) gonad, sex-determining region of the Y (SRY) protein acts to up-regulate expression of the related gene, SOX9, a transcriptional regulator that in turn initiates a downstream p...

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Autors principals: Bogani, Debora, Siggers, Pam, Brixey, Rachel, Warr, Nick, Beddow, Sarah, Edwards, Jessica, Williams, Debbie, Wilhelm, Dagmar, Koopman, Peter, Flavell, Richard A., Chi, Hongbo, Ostrer, Harry, Wells, Sara, Cheeseman, Michael, Greenfield, Andy
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2009
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2733150/
https://ncbi.nlm.nih.gov/pubmed/19753101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1000196
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