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Functionally Relevant Domains of the Prion Protein Identified In Vivo
The prion consists essentially of PrP(Sc), a misfolded and aggregated conformer of the cellular protein PrP(C). Whereas PrP(C) deficient mice are clinically healthy, expression of PrP(C) variants lacking its central domain (PrP(ΔCD)), or of the PrP-related protein Dpl, induces lethal neurodegenerati...
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| Autors principals: | , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Public Library of Science
2009
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2733036/ https://ncbi.nlm.nih.gov/pubmed/19738901 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0006707 |
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