The G-Quadruplex Ligand Telomestatin Impairs Binding of Topoisomerase IIIα to G-Quadruplex-Forming Oligonucleotides and Uncaps Telomeres in ALT Cells

In Alternative Lengthening of Telomeres (ALT) cell lines, specific nuclear bodies called APBs (ALT-associated PML bodies) concentrate telomeric DNA, shelterin components and recombination factors associated with telomere recombination. Topoisomerase IIIα (Topo III) is an essential telomeric-associat...

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Autores principales: Temime-Smaali, Nassima, Guittat, Lionel, Sidibe, Assitan, Shin-ya, Kazuo, Trentesaux, Chantal, Riou, Jean-François
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2009
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2732903/
https://ncbi.nlm.nih.gov/pubmed/19742304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0006919
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