Uncoupling CD21 and CD19 of the B-cell coreceptor

Complement receptors (CRs) CD21 and CD35 form a coreceptor with CD19 and CD81 on murine B cells that when coligated with the B-cell receptor lowers the threshold of activation by several orders of magnitude. This intrinsic signaling role is thought to explain the impaired humoral immunity of mice be...

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Bibliografiske detaljer
Main Authors: Barrington, Robert A., Schneider, Thomas J., Pitcher, Lisa A., Mempel, Thorsten R., Ma, Minghe, Barteneva, Natasha S., Carroll, Michael C.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2009
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2732852/
https://ncbi.nlm.nih.gov/pubmed/19706534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0903477106
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