Galectin-3 negatively regulates TCR-mediated CD4(+) T-cell activation at the immunological synapse

We have investigated the function of endogenous galectin-3 in T cells. Galectin-3-deficient (gal3(−/−)) CD4(+) T cells secreted more IFN-γ and IL-4 than gal3(+/+)CD4(+) T cells after T-cell receptor (TCR) engagement. Galectin-3 was recruited to the cytoplasmic side of the immunological synapse (IS)...

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Hoofdauteurs: Chen, Huan-Yuan, Fermin, Agnes, Vardhana, Santosh, Weng, I-Chun, Lo, Kin Fong Robin, Chang, En-Yuh, Maverakis, Emanual, Yang, Ri-Yao, Hsu, Daniel K, Dustin, Michael L., Liu, Fu-Tong
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2009
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2732795/
https://ncbi.nlm.nih.gov/pubmed/19706535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0903497106
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