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Galectin-3 negatively regulates TCR-mediated CD4(+) T-cell activation at the immunological synapse
We have investigated the function of endogenous galectin-3 in T cells. Galectin-3-deficient (gal3(−/−)) CD4(+) T cells secreted more IFN-γ and IL-4 than gal3(+/+)CD4(+) T cells after T-cell receptor (TCR) engagement. Galectin-3 was recruited to the cytoplasmic side of the immunological synapse (IS)...
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| Hlavní autoři: | , , , , , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
2009
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2732795/ https://ncbi.nlm.nih.gov/pubmed/19706535 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0903497106 |
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