Selective activation of the M(1) muscarinic acetylcholine receptor achieved by allosteric potentiation

The forebrain cholinergic system promotes higher brain function in part by signaling through the M(1) muscarinic acetylcholine receptor (mAChR). During Alzheimer's disease (AD), these cholinergic neurons degenerate, therefore selectively activating M(1) receptors could improve cognitive functio...

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Bibliografiset tiedot
Päätekijät: Ma, Lei, Seager, Matthew A., Wittmann, Marion, Jacobson, Marlene, Bickel, Denise, Burno, Maryann, Jones, Keith, Graufelds, Valerie Kuzmick, Xu, Guangping, Pearson, Michelle, McCampbell, Alexander, Gaspar, Renee, Shughrue, Paul, Danziger, Andrew, Regan, Christopher, Flick, Rose, Pascarella, Danette, Garson, Susan, Doran, Scott, Kreatsoulas, Constantine, Veng, Lone, Lindsley, Craig W., Shipe, William, Kuduk, Scott, Sur, Cyrille, Kinney, Gene, Seabrook, Guy R., Ray, William J.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2009
Aiheet:
Biological Sciences
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2732705/
https://ncbi.nlm.nih.gov/pubmed/19717450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0900903106
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