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Failure of CDKN2A/B (INK4A/B–ARF)-mediated tumor suppression and resistance to targeted therapy in acute lymphoblastic leukemia induced by BCR-ABL

Deletions of the CDKN2A/B tumor suppressor locus and of the IKAROS and PAX5 genes that promote B-lineage development occur frequently in lymphoid, but not myeloid leukemias initiated by the BCR-ABL tyrosine kinase. Why is this the case, and how do these genetic lesions contribute to an aggressive di...

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Detalles Bibliográficos
Main Authors: Mullighan, Charles G., Williams, Richard T., Downing, James R., Sherr, Charles J.
Formato: Artigo
Idioma:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2008
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2732413/
https://ncbi.nlm.nih.gov/pubmed/18519632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1673908
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