Arf gene loss enhances oncogenicity and limits imatinib response in mouse models of Bcr-Abl-induced acute lymphoblastic leukemia

Mouse bone marrow cells transduced with retroviral vectors encoding either of two oncogenic Bcr-Abl isoforms (p210(Bcr-Abl) and p185(Bcr-Abl)) induce B cell lympholeukemias when transplanted into lethally irradiated mice. If the activity of the Arf tumor suppressor is compromised, these donor cells...

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Detaylı Bibliyografya
Asıl Yazarlar: Williams, Richard T., Roussel, Martine F., Sherr, Charles J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2006
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1440588/
https://ncbi.nlm.nih.gov/pubmed/16618932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0602030103
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