Gene–environment interactions in Leber hereditary optic neuropathy

Leber hereditary optic neuropathy (LHON) is a genetic disorder primarily due to mutations of mitochondrial DNA (mtDNA). Environmental factors are thought to precipitate the visual failure and explain the marked incomplete penetrance of LHON, but previous small studies have failed to confirm this to...

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Detalhes bibliográficos
Main Authors: Kirkman, Matthew Anthony, Yu-Wai-Man, Patrick, Korsten, Alex, Leonhardt, Miriam, Dimitriadis, Konstantin, De Coo, Ireneaus F., Klopstock, Thomas, Chinnery, Patrick Francis
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2009
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2732267/
https://ncbi.nlm.nih.gov/pubmed/19525327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awp158
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