Gene–environment interactions in Leber hereditary optic neuropathy

Leber hereditary optic neuropathy (LHON) is a genetic disorder primarily due to mutations of mitochondrial DNA (mtDNA). Environmental factors are thought to precipitate the visual failure and explain the marked incomplete penetrance of LHON, but previous small studies have failed to confirm this to...

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Библиографические подробности
Главные авторы: Kirkman, Matthew Anthony, Yu-Wai-Man, Patrick, Korsten, Alex, Leonhardt, Miriam, Dimitriadis, Konstantin, De Coo, Ireneaus F., Klopstock, Thomas, Chinnery, Patrick Francis
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2009
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Original Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2732267/
https://ncbi.nlm.nih.gov/pubmed/19525327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awp158
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