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Self-Association of Human PCSK9 Correlates with Its LDLR-Degrading Activity
Genetic studies have demonstrated an important role for proprotein convertase subtilisin/kexin type 9 (PCSK9) as a determinant of plasma cholesterol levels. However, the underlying molecular mechanism is not completely understood. To this end, we have generated a mammalian cell expression system for...
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| Main Authors: | , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2008
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2732112/ https://ncbi.nlm.nih.gov/pubmed/18197702 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi7016359 |
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