Novel Domain Interaction Regulates Secretion of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Protein

PCSK9 (proprotein convertase subtilisin/kexin type 9) has emerged as a novel therapeutic target for hypercholesterolemia due to its LDL receptor (LDLR)-reducing activity. Although its structure has been solved, the lack of a detailed understanding of the structure-function relation hinders efforts t...

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Bibliographic Details
Main Authors: Du, Fen, Hui, Yvonne, Zhang, Michelle, Linton, MacRae F., Fazio, Sergio, Fan, Daping
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Molecular Bases of Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3234880/
https://ncbi.nlm.nih.gov/pubmed/22027821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.273474
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