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The endocytic pathway mediates cell entry of dsRNA to induce RNAi silencing

Many metazoan cells can take up exogenous double-stranded (ds) RNA and use it to initiate an RNA silencing response, however, the mechanism for this uptake is ill-defined. Here, we identify the pathway for dsRNA uptake in Drosophila melanogaster S2 cells. Biochemical and cell biological analyses, an...

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Bibliografiske detaljer
Main Authors: Saleh, Maria-Carla, van Rij, Ronald P., Hekele, Armin, Gillis, Amethyst, Foley, Edan, O’Farrell, Patrick H., Andino, Raul
Format: Artigo
Sprog:Inglês
Udgivet: 2006
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2731564/
https://ncbi.nlm.nih.gov/pubmed/16862146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncbl439
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