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Mechanisms and clinical prospects of Notch inhibitors in the therapy of hematological malignancies
Activation of Notch signaling has been implicated in pathogenesis of various hematologic tumors including leukemias, lymphomas, and multiple myeloma. Pre-clinical studies have suggested that inhibition of Notch could be an attractive new approach to treatment of hematologic malignancies. This review...
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| Главные авторы: | , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2008
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2731237/ https://ncbi.nlm.nih.gov/pubmed/18951834 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.drup.2008.09.002 |
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