Bone Morphogenetic Protein Antagonist Noggin Promotes Skin Tumorigenesis via Stimulation of the Wnt and Shh Signaling Pathways

Bone morphogenetic proteins (BMPs) play pivotal roles in the regulation of skin development. To study the role of BMPs in skin tumorigenesis, BMP antagonist noggin was used to generate keratin 14-targeted transgenic mice. In contrast to wild-type mice, transgenic mice developed spontaneous hair foll...

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Autors principals: Sharov, Andrey A., Mardaryev, Andrei N., Sharova, Tatyana Y., Grachtchouk, Marina, Atoyan, Ruzanna, Byers, H. Randolph, Seykora, John T., Overbeek, Paul, Dlugosz, Andrzej, Botchkarev, Vladimir A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Investigative Pathology 2009
Matèries:
Regular Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2731148/
https://ncbi.nlm.nih.gov/pubmed/19700758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2009.090163
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