Snapshot of a reaction intermediate: analysis of benzoylformate decarboxylase in complex with a benzoylphosphonate inhibitor

Benzoylformate decarboxylase (BFDC) is a thiamin diphosphate (ThDP)-dependent enzyme acting on aromatic substrates. In addition to its metabolic role in the mandelate pathway, BFDC shows broad substrate specificity coupled with tight stereocontrol in the carbon-carbon bond-forming reverse reaction,...

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Hlavní autoři: Brandt, Gabriel S., Kneen, Malea M., Chakraborty, Sumit, Baykal, Ahmet T., Nemeria, Natalia, Yep, Alejandra, Ruby, David I., Petsko, Gregory A., Kenyon, George L., McLeish, Michael J., Jordan, Frank, Ringe, Dagmar
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2730839/
https://ncbi.nlm.nih.gov/pubmed/19320438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi801950k
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