The inhibitors of histone deacetylase suberoylanilide hydroxamate and trichostatin A release nitric oxide upon oxidation

Suberoylanilide hydroxamic acid (SAHA, vorinostat, Zolinza®) is the lead compound of a new class of histone deacetylase (HDAC) inhibitors used as anticancer drugs, which have been shown to affect multiple proteins associated with gene expression, cell proliferation and migration. Studies have also d...

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Библиографические подробности
Главные авторы: Samuni, Yuval, Flores-Santana, Wilmarie, Krishna, Murali C., Mitchell, James B., Wink, David A.
Формат: Artigo
Язык:Inglês
Опубликовано: 2009
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2730666/
https://ncbi.nlm.nih.gov/pubmed/19447172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2009.05.011
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