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Suberoylanilide hydroxamic acid radiosensitizes tumor hypoxic cells in vitro through the oxidation of nitroxyl to nitric oxide

The pharmacological effects of hydroxamic acids are partially attributed to their ability to serve as HNO and/or NO donors under oxidative stress. Previously, it was concluded that oxidation of the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) by the metmyoglobin/H(2)O(2) reac...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Free Radic Biol Med
Main Authors: Samuni, Yuval, Wink, David A., Krishna, Murali C., Mitchell, James B., Goldstein, Sara
פורמט: Artigo
שפה:Inglês
יצא לאור: 2014
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC7670884/
https://ncbi.nlm.nih.gov/pubmed/24880052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2014.05.019
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