Ascorbic Acid Promotes Detoxification and Elimination of 4-Hydroxy-2(E)-nonenal in Human Monocytic THP-1 Cells

4-Hydroxy-2(E)-nonenal (HNE), a reactive aldehyde derived from oxidized lipids, has been implicated in the pathogenesis of cardiovascular and neurological diseases, in part by its ability to induce oxidative stress and by protein carbonylation in target cells. The effects of intracellular ascorbic a...

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Bibliographic Details
Main Authors: Miranda, Cristobal L., Reed, Ralph L., Kuiper, Heather C., Alber, Susan, Stevens, Jan F.
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2730585/
https://ncbi.nlm.nih.gov/pubmed/19326901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx900042u
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