Transmitochondrial embryonic stem cells containing pathogenic mtDNA mutations are compromised in neuronal differentiation

Objectives:  Defects of the mitochondrial genome (mtDNA) cause a series of rare, mainly neurological disorders. In addition, they have been implicated in more common forms of movement disorders, dementia and the ageing process. In order to try to model neuronal dysfunction associated with mitochondr...

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Detalhes bibliográficos
Main Authors: Kirby, D. M. , Rennie, K. J. , Smulders‐Srinivasan, T. K. , Acin‐Perez, R. , Whittington, M. , Enriquez, J.‐A. , Trevelyan, A. J. , Turnbull, D. M. , Lightowlers, R. N. 
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2009
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2730481/
https://ncbi.nlm.nih.gov/pubmed/19552636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2184.2009.00612.x
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