Inhibition of the CXCR4/CXCL12 chemokine pathway reduces the development of murine pulmonary metastases

Metastasis continues to be the leading cause of mortality for patients with cancer. High expression of the chemokine receptor CXCR4 correlates with poor prognosis in many cancers, including osteosarcoma and melanoma. CXCL12, the ligand for CXCR4, is expressed at high levels in the lung and lymph nod...

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Autori principali: Kim, Su Young, Lee, Chih Hung, Midura, Brieanne V., Yeung, Choh, Mendoza, Arnulfo, Hong, Sung Hyeok, Ren, Ling, Wong, Donald, Korz, Walter, Merzouk, Ahmed, Salari, Hassan, Zhang, Hong, Hwang, Sam T., Khanna, Chand, Helman, Lee J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2007
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2730112/
https://ncbi.nlm.nih.gov/pubmed/18071913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10585-007-9133-3
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