Epithelial chemokine CXCL14 synergizes with CXCL12 via allosteric modulation of CXCR4

The chemokine receptor, CXC chemokine receptor 4 (CXCR4), is selective for CXC chemokine ligand 12 (CXCL12), is broadly expressed in blood and tissue cells, and is essential during embryogenesis and hematopoiesis. CXCL14 is a homeostatic chemokine with unknown receptor selectivity and preferential e...

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Veröffentlicht in:FASEB J
Hauptverfasser: Collins, Paul J., McCully, Michelle L., Martínez-Muñoz, Laura, Santiago, César, Wheeldon, James, Caucheteux, Stephan, Thelen, Sylvia, Cecchinato, Valentina, Laufer, Julia M., Purvanov, Vladimir, Monneau, Yoan R., Lortat-Jacob, Hugues, Legler, Daniel F., Uguccioni, Mariagrazia, Thelen, Marcus, Piguet, Vincent, Mellado, Mario, Moser, Bernhard
Format: Artigo
Sprache:Inglês
Veröffentlicht: Federation of American Societies for Experimental Biology 2017
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Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5472405/
https://ncbi.nlm.nih.gov/pubmed/28360196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201700013R
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