Eradication of Chronic Myeloid Leukemia Stem Cells: A Novel Mathematical Model Predicts No Therapeutic Benefit of Adding G-CSF to Imatinib

Imatinib mesylate induces complete cytogenetic responses in patients with chronic myeloid leukemia (CML), yet many patients have detectable BCR-ABL transcripts in peripheral blood even after prolonged therapy. Bone marrow studies have shown that this residual disease resides within the stem cell com...

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Bibliografiske detaljer
Main Authors: Foo, Jasmine, Drummond, Mark W., Clarkson, Bayard, Holyoake, Tessa, Michor, Franziska
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2009
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2730033/
https://ncbi.nlm.nih.gov/pubmed/19749982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1000503
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