The Inhibitory Effect of siRNAs on The High Glucose-Induced Overexpression of TGF-β1 in Mesangial Cells

Diabetic nephropathy is characterized by an expansion of the glomerular mesangium, caused by mesangial cell proliferation and an excessive accumulation of extracellar matrix (ECM) proteins, which eventually leading to glomerulosclerosis. TGF-β1 was found to play an important role in the accumulation...

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Главные авторы: Noh, Hey-Jeong, Kim, Hyun-Chul, Lee, Sang-Sook, Kang, Yu-Na, Chae, Young-Mi, Park, Kwan-Kyu
Формат: Artigo
Язык:Inglês
Опубликовано: The Korean Academy of Medical Sciences 2006
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Original Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2729946/
https://ncbi.nlm.nih.gov/pubmed/16778384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3346/jkms.2006.21.3.430
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