Sequence characteristics of functional siRNAs

RNA interference in mammalian cells is actively used to conduct genetic screens, to identify and to validate targets, and to elucidate regulators and modifiers of cellular pathways. To ensure the specificity and efficacy of the active 21mer siRNA molecules, it is pertinent to develop a strategy for...

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Detalles Bibliográficos
Autores principales: JAGLA, BERND, AULNER, NATHALIE, KELLY, PETER D., SONG, DA, VOLCHUK, ALLEN, ZATORSKI, ANDRZEJ, SHUM, DAVID, MAYER, THOMAS, DE ANGELIS, DINO A., OUERFELLI, OUATHEK, RUTISHAUSER, URS, ROTHMAN, JAMES E.
Formato: Artigo
Lenguaje:Inglês
Publicado: Copyright 2005 by RNA Society 2005
Materias:
Bioinformatics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1370771/
https://ncbi.nlm.nih.gov/pubmed/15923373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.7275905
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