Sequence characteristics of functional siRNAs

RNA interference in mammalian cells is actively used to conduct genetic screens, to identify and to validate targets, and to elucidate regulators and modifiers of cellular pathways. To ensure the specificity and efficacy of the active 21mer siRNA molecules, it is pertinent to develop a strategy for...

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Detalhes bibliográficos
Main Authors: JAGLA, BERND, AULNER, NATHALIE, KELLY, PETER D., SONG, DA, VOLCHUK, ALLEN, ZATORSKI, ANDRZEJ, SHUM, DAVID, MAYER, THOMAS, DE ANGELIS, DINO A., OUERFELLI, OUATHEK, RUTISHAUSER, URS, ROTHMAN, JAMES E.
Formato: Artigo
Idioma:Inglês
Publicado em: Copyright 2005 by RNA Society 2005
Assuntos:
Bioinformatics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1370771/
https://ncbi.nlm.nih.gov/pubmed/15923373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.7275905
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